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Ouchi, Noriyuki
Data Science Journal (Internet), 6(Suppl.), p.S278 - S284, 2007/05
Biological effects of low-dose radiation are studied by computational methods. Assessing the risks of low-dose radiation, i.e. radiation induced cancer, is getting worth for the study of public health due to many types of exposures, medical exposures, and for the radiation protection view points. Here we introduce our on going study of describing low-dose radiation effects. Computer modeling and simulation are quite effective to clarify the mechanism of radiation effects since a phenomenon taking place in a small region in a very short time can be observed which is difficult to examine by experimental approaches. We will show our researches concerning the 3 stages of the radiation effects from atomic level to cellular level, (1) Simulation of DNA strand breaks by ionizing radiation, (2) Molecular dynamical study of the DNA lesion repair, (3) modeling and simulation of the cellular level tumorigenesis.
Kaji, Yoshiyuki; Tsuji, Hirokazu; Fujita, Mitsutane*; Xu, Y.*; Yoshida, Kenji*; Mashiko, Shinichi*; Shimura, Kazuki*; Miyakawa, Shunichi*; Ashino, Toshihiro*
Data Science Journal (Internet), 3, p.88 - 94, 2004/07
The distributed material database system named "Data-Free-Way" has been developed by four organizations (the National Institute for Materials Science, the Japan Atomic Energy Research Institute, the Japan Nuclear Cycle Development Institute, and the Japan Science and Technology Corporation) under a cooperative agreement. In order to create additional values of the system, knowledge base system, in which knowledge extracted from the material database is expressed, is planned to be developed for more effective utilization of Data-Free-Way. XML (eXtensible Markup Language) has been adopted as the description method of the retrieved results and the meaning of them. One knowledge note described with XML is stored as one knowledge which composes the knowledge base. This paper describes the current status of Data-Free-Way, the description method of knowledge extracted from the material database with XML and the distributed material knowledge base system.
